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一、定义:顾名思意,药源性急性肌张力障碍系指药物治疗所致的一种肌张力障碍,多发生在药物治疗的初期,主要由神经安定剂所致的一种副反应。其他药物虽然也可以导致这类反应,但不是本文讨论的重点。二、发生率:急性肌张力障碍是神经安定剂治疗所致锥外系统反应中最常见和最早期的一种症状。Ayd早期估计酚噻嗪药物引起这类反应约占2～5%。后来Swett等人认为效价更强的氟哌啶醇以及长效氟癸酯所致的急性肌张力障碍的发生率分别为16%和25%。事实上,随着药量增大,锥外系统反应也随之增多,而急性肌张力障碍的发生率远不止此。三、临床症状: 神经安定剂治疗诱发的急性肌张力障碍的临床表现,早在五十年代就有Delay等
First, the definition: As the name suggests, drug-induced acute dystonia refers to a kind of dystonia caused by drug treatment, occurred in the early stages of drug treatment, mainly due to neurotransmitters caused by a side reaction. Although other drugs can also cause such reactions, but not the focus of this article. Second, the incidence: Acute dystonia is the most common and earliest symptoms of extrapyramidal systemic responses due to neuroleptic agents. Ayd early estimates phenothiazine drugs cause such reactions accounted for about 2 to 5%. Later, Swett et al. Identified 16% and 25%, respectively, of acute dystonia due to more potent haloperidol and long-acting fluorodecyl ester. In fact, as dosing increases, so does the extrapyramidal response, and the incidence of acute dystonia goes far beyond this. Third, the clinical symptoms: neuroleptic agent-induced clinical manifestations of acute dystonia, as early as the fifties there Delay, etc.