目的探讨青年乳腺癌与中老年乳腺癌的临床特点和预后。方法回顾性分析湖南省肿瘤医院1987年 1月至 1991年 12月收治的 4 0 9例临床Ⅰ～Ⅲ期乳腺癌资料 ,将其分为青年组 (≤ 35岁 ) (A组 )和中老年组 (>35岁 ) (B组 )。A组 6 7例 ,B组 342例 ,比较两组的临床资料。结果临床Ⅱ期A组 (4 9.3%)少于B组 (6 4 .3%) (P <0 .0 5 ) ,Ⅲ期A组 (38.8%)多于B组 (2 4 .0 %) (P <0 .0 5 ) ;肿瘤大小、病理类型、淋巴结转移情况、雌孕激素受体状况、手术方式、综合治疗方式和生存率两组相比均无统计学差异 (P >0 .0 5 )。A组和B组的 3年、5年生存率分别是 90 .76 %、6 7.2 9%和 86 .0 0 %、71.90 %,两组比较无统计学差异 (P >0 .0 5 )。结论本研究提示青年乳腺癌一旦发现即采取积极治疗 ,可能取得与中老年乳腺癌一样的效果 ,年龄不一定是影响预后的独立因素  Objective  To investigate the clinical features and prognosis of young and middle-aged breast cancer. Methods  Retrospective analysis of 409 cases of stage Ⅰ ~ Ⅲ breast cancer data from Hunan Cancer Hospital from January 1987 to December 1991 were divided into young group (≤35 years old) (group A) and Middle-aged and elderly (> 35 years old) (group B). A group of 67 cases, B group 342 cases, the clinical data of two groups were compared. Results  The clinical stage A group (4 9.3%) was less than the B group (64.4%) (P <0.05), stage III A group (38.8%) than the B group (24.0 %) (P <0.05). There was no significant difference in tumor size, pathological type, lymph node metastasis, estrogen and progesterone receptor status, operation mode, comprehensive treatment and survival rate between the two groups (P> 0.05) .0 5). The 3-year and 5-year survival rates of group A and group B were 90.76%, 62.29% and 86.0%, 71.90% respectively, with no significant difference between the two groups (P> 0.05).  Conclusion  This study suggests that once breast cancer is found to be aggressive treatment, breast cancer may achieve the same effect, and age is not necessarily an independent prognostic factor