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目的 了解肾移植术后恶性肿瘤的发病情况、类型及治疗效果。方法 回顾性分析1977～ 1999年同种肾移植术 12 86次 / 113 2人 ,术后肿瘤的发生情况和免疫抑制剂使用情况。结果 共发生恶性肿瘤 19例 ,发生率 1.67% ,分别发生于移植术后 5～ 12 6个月 ,平均 5 7个月。其中泌尿系肿瘤 11例 ,肝癌、肺癌各 2例 ,胃癌、乙状结肠癌、乳腺癌、恶性淋巴瘤各 1例。 13例行手术治疗 ,现存活 10例 ,平均存活期 2 0个月 ,7例属肿瘤病变晚期 ,短期内死亡 ,1例死于感染引起的中毒性休克 ,1例死于肝功能衰竭。结论 肾移植术后恶性肿瘤的发生率明显提高 ,以泌尿系肿瘤最常见 ,治疗上应争取尽早手术切除肿瘤。
Objective To understand the incidence of malignant tumors after kidney transplantation, type and treatment effect. Methods Retrospective analysis of the same type of renal transplantation from 1977 to 1999, 12 86 times / 113 2 people, the incidence of postoperative tumor and the use of immunosuppressive agents. Results A total of 19 cases of malignant tumors occurred, the incidence rate was 1.67%, which occurred in 5 ~ 126 months after transplantation, with an average of 57 months. Including urinary tract tumors in 11 cases, liver cancer, lung cancer in 2 cases, gastric cancer, sigmoid colon cancer, breast cancer, one case of malignant lymphoma. Thirteen patients underwent surgical treatment. Ten survivors were alive and the mean survival time was 20 months. Seven patients were late-stage and died within a short period of time. One died of toxic shock caused by infection and one died of liver failure. Conclusion The incidence of malignant neoplasms after renal transplantation is obviously increased. Urinary tumors are the most common and the tumors should be surgically removed for treatment.