目的 :探讨非穿透性小梁手术 (NPTS)联合羊膜移植治疗开角型青光眼的机制及疗效评价。寻找透明质酸钠凝胶植入材料替代物。方法 :对 18例 2 5只开角型青光眼患者行非穿透性小梁手术联合羊膜移植 ,术后观察视力、眼压、滤过泡及眼内反应 ,随访时间最短 30天 ,最长 4 2 0天。结果 :术前 2 5只眼平均眼压为 (38 2± 14 4 )mmHg ,2 5只眼术后 3只眼眼压高于 2 1mmHg ,经降眼压药物治疗后 2只眼仍高达 2 8mmHg以上 ,余眼压均控制在 7～ 2 0mmHg之内 ,术后 2个月手术成功率为 88% ,条件成功率为 92 % ,术后 3个月手术成功率为 82 % ,条件成功率为 88%。术后视力均有显著提高 ,滤过泡扁平弥漫 ,轻微充血。术中、术后未出现浅前房、前房出血、玻璃体脱出、脉络膜脱离等并发症。结论 :非穿透性小梁手术联合羊膜移植能安全、有效地降低眼压 ,为非穿透性小梁手术提供了有效安全植入材料。可广泛用于开角型青光眼的治疗 Objective: To investigate the mechanism and efficacy of non-penetrating trabecular meshwork (NPTS) combined with amniotic membrane transplantation for open-angle glaucoma. Look for hyaluronate sodium gel implant material substitutes. Methods: 18 cases of 25 open-angle glaucoma patients underwent non-penetrating trabecular surgery combined with amniotic membrane transplantation. Visual acuity, intraocular pressure, filtration bleb and intraocular reaction were observed after operation. The shortest follow-up time was 30 days and the longest time was 4 20 days. Results: The mean IOP of 25 eyes before operation was (38 2 ± 14 4) mmHg. The intraocular pressure of 3 eyes was higher than 21 mmHg after operation in 25 eyes. The IOP of 2 eyes was still 2 8mmHg or more, the remaining intraocular pressure were controlled within 7 ~ 20mmHg, 2 months after surgery, the success rate was 88%, the successful rate was 92%, 3 months after surgery, the success rate was 82%, the conditional success rate 88%. Postoperative visual acuity was significantly improved, the perforation flattened diffuse, slightly hyperemia. Intraoperative and postoperative did not appear shallow anterior chamber, anterior chamber bleeding, vitreous prolapse, choroidal detachment and other complications. CONCLUSION: Non-penetrating trabecular surgery combined with amniotic membrane transplantation can reduce intraocular pressure safely and effectively and provide an effective and safe implant for non-penetrating trabecular surgery. Can be widely used for the treatment of open angle glaucoma