在胰岛素依赖型糖尿病(IDDM)中,免疫抑制可阻止胰腺β细胞的受累过程,此外,尚有证据表明可以预测该病患者一级亲属 IDDM 的发生,因此美国糖尿病学会及其他组织已进行了预防性干预的效果与安全性的临床研究。在体外,烟酰胺可抑制杀伤β细胞的巨噬细胞激活,并可降低鼠β细胞上的Ⅱ型主要组织相容复合物(MHC)的诱导. In insulin-dependent diabetes mellitus (IDDM), immunosuppression prevents the process of pancreatic β-cell involvement. In addition, there is evidence that predicting the occurrence of IDDM in first-degree relatives of patients with this disease and therefore the American Diabetes Association and others have been prophylactic Clinical study on the effect and safety of sexual intervention. In vitro, nicotinamide inhibits the activation of macrophages that kill beta cells and reduces the induction of type II major histocompatibility complex (MHC) on rat beta cells.