1862年雷诺(Raynaud)氏首先提出了一种由于间歇性肢端小动脉痉挛导致局部皮肤苍白,继之紫绀、发红的周围血管疾病,可分为原发性和继发性,前者病因不明,称雷诺氏病,后者继发于结缔组织病、冷凝集素血症、冷球蛋白血症及神经系 1862 Renault (Raynaud) first proposed a due to intermittent acral artery spasm resulting in partial pale skin, followed by cyanosis, redness of peripheral vascular disease can be divided into primary and secondary, the former etiology , Said Raynaud’s disease, the latter secondary to connective tissue disease, cold agglutinin, cryoglobulinemia and nervous system