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目的:探讨保妇康栓治疗宫颈高危型人乳头瘤病毒(HPV)感染的疗效。方法:采用病例对照研究方法,将本院门诊在2011年9月~2013年6月确定诊断为生殖道高危型HPV感染者,并同时进行宫颈液基细胞(TCT)及阴道镜检查排除宫颈癌前病变及宫颈癌的病例共计134例,随机分为观察组和对照组,观察组69例,给予保妇康栓阴道用药3个月。对照组65例,不用任何药物,进行观察。结果:2组患者用药3个月后停药1个月,宫颈高危型人乳头瘤病毒的转阴率分别为47.83%和13.85%,差异显著(P<0.01),有统计学意义。观察组宫颈炎痊愈率、有效率均明显高于对照组(P<0.01)。结论:保妇康栓具有抗菌、消炎作用,并能有效治疗HPV感染,值得临床广泛应用。
Objective: To investigate the effect of Baofukang Suppository on the treatment of cervical high risk human papillomavirus (HPV) infection. Methods: A case-control study was conducted to determine the diagnosis of genital high-risk HPV infection in our clinic from September 2011 to June 2013. Cervical liquid-based cells (TCT) and colposcopy were also performed to exclude cervical cancer A total of 134 cases of premalignant lesions and cervical cancer were randomly divided into observation group and control group. The observation group was given 69 cases with vaginal administration of Baofukang suppository for 3 months. Control group, 65 cases, without any drug, for observation. Results: The two groups of patients discontinued for 3 months after treatment for 1 month. The negative conversion rate of high risk HPV was 47.83% and 13.85%, respectively, with significant difference (P <0.01). Observation group of cervicitis cure rate, effective rate was significantly higher than the control group (P <0.01). Conclusion: Baofukang suppository has antibacterial and anti-inflammatory effects and can effectively treat HPV infection, which deserves wide application in clinic.