妊娠相关血浆蛋白A是金属结合蛋白酶锌指多肽超家族成员,可以通过调节胰岛素生长因子轴发挥促进细胞增殖、抑制凋亡、促进炎症因子分泌等功能.探讨妊娠相关血浆蛋白A在心血管疾病中的作用机制已成为国内外研究热点,现对近年来关于妊娠相关血浆蛋白A的生物学特性、信号传导通路及在心血管疾病中的基础与临床研究的新进展进行综述.“,”Pregnancy-associated plasma protein-A ( PAPP-A) is a zinc-binding metalloproteinase protein .PAPP-A can promote cell proliferation,inhibit apoptosis and promote the secretion of inflammatory factors by regulating the insulin -like growth factor ( IGF) axis. Recently,the role of PAPP-A in cardiovascular disease has become a research focus at home and abroad .In this review,we will introduce a complete description of PAPP-A structure , biology and molecular pathways , then present an updated overview of experimental as well as clinical and preclinical evidence of PAPP-A.