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目的:探讨磷酸肌酸辅助治疗新生儿窒息合并重度心肌损害的效果及对心肌酶谱的影响。方法:选取80例在苍南县人民医院治疗的窒息合并重度心肌损害的新生儿,随机分为观察组和对照组各40例。对照组患儿采用常规治疗,观察组患儿在对照组治疗的基础上加用磷酸肌酸,治疗时间为1周,观察两组治疗效果、心肌酶谱变化情况。结果:观察组总有效率为80.00%,显著高于对照组的47.50%(P<0.05);治疗后,观察组和对照组肌酸激酶(CK)、肌酸激酶同工酶(CK-MB)、乳酸脱氢酶(LDH)、α-羟丁酸脱氢酶(HBDH)、天冬氨酸氨基转移酶(AST)水平均较治疗前显著降低(P<0.05),且观察组患儿治疗后CK、CK-MB、LDH、HBDH、AST水平下降更显著(P<0.05)。结论:磷酸肌酸辅助治疗新生儿窒息合并重度心肌损害效果显著,可降低心肌酶谱水平,减少心肌损害。
Objective: To investigate the effect of creatine phosphate-assisted therapy on neonatal asphyxia with severe myocardial damage and its effect on myocardial enzymes. Methods: Eighty neonates with asphyxia and severe myocardial damage who were treated in Cangnan People’s Hospital were randomly divided into observation group (40 cases) and control group (40 cases). The control group of children with conventional treatment, the observation group children in the control group based on the addition of creatine phosphate therapy, the treatment time was 1 week, the two groups were observed therapeutic effect, changes in myocardial zymogram. Results: The total effective rate in the observation group was 80.00%, significantly higher than that in the control group (47.50%, P <0.05). After treatment, the levels of creatine kinase (CK), creatine kinase MB ), LDH, HBDH and AST were significantly lower than those before treatment (P <0.05), and the children in the observation group After treatment, the levels of CK, CK-MB, LDH, HBDH and AST decreased more significantly (P <0.05). Conclusion: Creatine phosphate-assisted adjuvant treatment of neonatal asphyxia with severe myocardial damage significantly, can reduce the level of myocardial enzymes, reduce myocardial damage.