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PDCD4是一种重要的肿瘤抑制因子,它在肿瘤细胞中的表达下降或缺失,与肿瘤的治疗和预后具有相关性。本文主要阐述PDCD4在细胞氧化应激和DNA损伤中对DNA修复中的影响作用,并阐述PDCD4与肿瘤治疗过程中的耐药性相关进展。最新研究结果不仅为PDCD4的分子机制研究提供良好理论依据,而且为肿瘤个体化治疗提供参考,同时PDCD4也成为新药物开发的潜在靶点分子。
PDCD4 is an important tumor suppressor, and its expression is down-regulated or absent in tumor cells, which is related to tumor treatment and prognosis. This article mainly expounds the effect of PDCD4 on DNA repair in cellular oxidative stress and DNA damage, and expounds the related progress of PDCD4 and drug resistance in the course of tumor treatment. The latest research not only provides a good theoretical basis for the molecular mechanism of PDCD4, but also provides a reference for the individualized treatment of cancer, and PDCD4 also becomes a potential target molecule for new drug development.