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目的：为了考察国产万拉法新胶囊治疗老年抑郁症的疗效、不良反应及其安全性。方法：通过随机双盲对照试验，共纳入万拉法新组１８例，阿米替林组２０例，用ＨＡＭＤ和ＨＡＭＡ量表在用药前及用药后４，７，１４，４２ｄ评定药物疗效；用ＴＥＳＳ量表评定其不良反应。结果：国产万拉法新胶囊对老年抑郁症治疗有效，有效率为８８．８９％，与阿米替林（８５．００％）相当（Ｐ＞０．０５）；其量表评定有效率８３．３３％，与阿米替林（８０．００％）相比，亦无显著性差异（Ｐ＞０．０５）；在不良反应方面与阿米替林相比，万拉法新治疗后ＴＥＳＳ植物神经系统、心血管系统、神经系统及其他系统因子分均明显降低，有显著性差异，而ＴＥＳＳ化验异常因子、行为毒性因子，两组相比无明显差异。万拉法新常见不良反应为头昏（２７．７８％）、头痛（２２．２２％）、便秘（１６．６７％）、口干（１６．６７％）、失眠（１６．６７％）、视物模糊（１１．１１％）、嗜睡（１１．１１％）、恶心（１１．１１％）和厌食（５．５５％）等。结论：国产万拉法新治疗老年抑郁症疗效肯定，不良反应明显少于阿米替林，值得临床推广应用
Objective: To investigate the curative effect, adverse reactions and safety of domestic venlafaxine capsules in the treatment of senile depression. Methods: Randomized double-blind controlled trials included 18 cases in venlafaxine group and 20 cases in amitriptyline group. HAMD and HAMA scale were used to evaluate the drug efficacy before and 4,7,14 and 42 days after treatment. TESS scale used to assess its adverse reactions. Results: Domestic venlafaxine capsules were effective in the treatment of geriatric depression with an effective rate of 88.89%, which was comparable to that of amitriptyline (85.00%) (P> 0.05). The effective rate of domestic venlafaxine capsules was 83 .33% compared with Amitriptyline (80.00%), there was no significant difference (P> 0.05); In adverse reactions compared with Amitriptyline, venlafaxine after treatment TESS plant Nervous system, cardiovascular system, nervous system and other system factors were significantly reduced, there were significant differences, and TESS assay abnormal factor, behavioral toxicity factors, there was no significant difference between the two groups. The common adverse reactions of venlafaxine were dizziness (27.78%), headache (22.22%), constipation (16.67%), dry mouth (16.67%), insomnia Blurred vision (11.11%), lethargy (11.11%), nausea (11.11%) and anorexia (5.55%). Conclusion: The domestic venlafaxine treatment of senile depression affirmative effect, adverse reaction was significantly less than amitriptyline, worthy of clinical application