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目的观察血液灌流联合透析在临床中治疗慢性肾功能衰竭(CRF)的效果。方法选取医院维持性血液透析时间在6个月以上的44例CRF患者,随机将患者分为对照组和观察组,每组22例。对照组采用透析治疗,而观察组将透析与血液灌流进行相互结合治疗;观察2组尿毒氮(BUN)、血清肌酐(SCr)、甲状旁腺激素(PTH)、血清磷(P)血液指标和皮肤瘙痒、睡眠、食欲、骨痛生活质量的变化情况。结果治疗后,对照组BUN、SCr水平与治疗前比较降低(P<0.05);观察组BUN、SCr、PTH、P数值与治疗前比较均降低(P<0.05);且观察组PTH、P降低幅度大于对照组(P<0.05)。观察组在皮肤瘙痒、睡眠、食欲和骨痛缓解率上均优于对照组(P<0.05或P<0.01)。结论血液灌流联合透析治疗方法可显著降低血液中BUN、SCr、PTH、P水平,提高慢性肾功能衰竭患者的生活质量,在临床中具有推广应用价值。
Objective To observe the clinical effect of hemoperfusion combined with dialysis in the treatment of chronic renal failure (CRF). Methods Forty-four patients with CRF whose hospital hemodialysis time was over 6 months were divided randomly into control group and observation group, with 22 patients in each group. The control group was treated with dialysis, while the observation group was treated with dialysis and hemoperfusion. The blood urea nitrogen (BUN), serum creatinine (SCr), parathyroid hormone (PTH) and serum phosphorus (P) Skin itching, sleep, appetite, bone pain, quality of life changes. Results After treatment, the levels of BUN and SCr in the control group were significantly lower than those before treatment (P <0.05); the values of BUN, SCr, PTH and P in the observation group were lower than those before treatment (P <0.05) Amplitude than the control group (P <0.05). The observation group was better than the control group in pruritus, sleep, appetite and bone pain relief rate (P <0.05 or P <0.01). Conclusion Hemoperfusion combined with dialysis treatment can significantly reduce the level of BUN, SCr, PTH, P in blood and improve the quality of life in patients with chronic renal failure, which has the value of popularization and application in clinic.