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随着人们生活水平的提高、人口老化、生活方式的改变,糖尿病患病率急剧升高,已是严重威胁人类健康的世界性公共卫生问题[1]。近年来国内外都有研究发现,2型糖尿病患者的恶性肿瘤发病率明显高于普通人群[2],而且2型糖尿病患者使用胰岛素治疗过程中,发生肿瘤的风险也有所增加[3-4]。因此,全面而深入地了解2型糖尿病与恶性肿瘤发生的关系是临床上亟待解决的科学问题;尽管目前已有多种学说试图对此进行解释,但仍没有一致意见。细胞自噬是将细胞内受损、变性或衰老的蛋白质以及细胞器
With the improvement of people’s living standards, population aging, lifestyle change, and the rapid increase of the prevalence of diabetes, it has become a worldwide public health problem that seriously threatens human health [1]. In recent years, studies have found that at home and abroad, the incidence of malignant tumors in patients with type 2 diabetes was significantly higher than the general population [2], and type 2 diabetes patients using insulin therapy, the risk of cancer also increased [3-4] . Therefore, a comprehensive and in-depth understanding of the relationship between type 2 diabetes and the development of malignant tumors is a clinically urgent scientific issue; although there are many theories that attempt to explain this, there is still no consensus. Autophagy is a protein, organelle, that damages, degenerates or senesces cells