大约 5 0 %的肿瘤有 ｐ5 3基因缺失和 /或突变 ,可见它和癌症的关系非常密切 ,目前研究较多的几种 ｐ5 3相关因素与ｐ5 3存在着复杂的制约关系 ,这种制约关系在肿瘤研究中越来越受到重视。1　ｐ5 3基因突变与 ｐ5 3启动子甲基化ｐ5 3基因突变常为一个或多个点的突变 ,如在乳腺 Approximately 50% of the tumors have the deletion and / or mutation of the p5 3 gene, showing that it has a close relationship with cancer. Currently, there are several complicated relationships between p5 3 -related factors and p5 3. In tumor research more and more attention. 1 p5 3 gene mutation and p5 3 promoter methylation p5 3 gene mutations often one or more point mutations, such as in the breast