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抗生素８９－０７按每天３０、１００和１８０ｍｇ／ｋｇｉｐ给予大鼠，连续９０天，共检测７项血液学指标，１０项生化指标及２０多种组织脏器，给药后头２周内，１８０ｍｇ组部分动物出现行走缓慢，有３只动物死于给药后１７～２１天。３０天测定时，１００和１８０ｍｇ组的肌酐和尿素氮含量升高。病理组织学检查仅见肾小管上皮细胞呈水泡样变和混浊肿胀及散在性的坏死，１８０ｍｇ组比１００ｍｇ组重。上述变化停药后均呈恢复趋势。本试验揭示抗生素８９－０７的主要毒性靶器官是肾脏，１００ｍｇ以上剂量是中毒和致死剂量，３０ｍｇ以下剂量属基本安全剂量。
Antibiotics 89-07 were administered to rats at 30, 100 and 180 mg / kg ip daily for 90 consecutive days. Seven hematological and 10 biochemical indices and more than 20 tissue organs were tested. Within the first 2 weeks after administration, 180 mg Some animals appeared to walk slowly, and three animals died 17 to 21 days after administration. At 30 days, creatinine and urea nitrogen levels increased in the 100 and 180 mg groups. Histopathological examination showed only vesicular epithelial cells were blister-like and turbid swelling and scattered necrosis, 180mg group than the 100mg group weight. The changes after withdrawal showed a recovery trend. The test revealed that the main toxic target organ of 89-07 is the kidney, 100mg and above dose is toxic and lethal dose, 30mg the following dose is a basic safe dose.