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目的观察阿尔茨海默病(Alzheimer’s disease,AD)发病进程中松果体的MRI形态学改变。方法依据AD发病进程,分别采集NC组24例、MCI组18例、轻度AD组16例、中-重度AD组20例受试者大脑MRI扫描图像,测量松果体矢径、横径、高、体积,并分析组间各测量值变化趋势。结果松果体标化高MCI期、轻度AD期较NC组增大(P<0.05),中-重度AD期标化高较MCI期、轻度AD缩小(P<0.05);松果体标化矢径、标化横径、标化体积MCI期、轻度AD、中-重度AD与NC组比无明显变化(P>0.05),但中-重度AD较MCI期组缩小(P<0.05)。结论在AD发病进程中松果体高先增大再萎缩,松果体高对MCI期、轻度AD患者的诊断有较大价值。
Objective To observe the morphological changes of pineal gland in the pathogenesis of Alzheimer’s disease (AD). Methods According to the course of AD, 24 cases of NC group, 18 cases of MCI group, 16 cases of mild AD group and 20 cases of moderate and severe AD group were respectively taken MRI scan of the brain to measure the mean diameter, High, volume, and analysis of changes in the measured values between groups. Results The normalized MCI stage and mild AD stage of pineal gland were higher than those of NC group (P <0.05). The normalization of moderate-severe AD stage was higher than that of MCI stage and mild AD (P <0.05) There was no significant difference in normalized radius, normalized transverse diameter, normalized volume MCI, mild AD, moderate-severe AD and NC (P> 0.05), but moderate-severe AD decreased compared with MCI (P < 0.05). Conclusions The pineal body mass firstly increases and then shrinks again in the course of AD. The pineal height is of great value in the diagnosis of MCI and mild AD.