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遗传因素所致的重度耳聋据各家报告占3.7～30,1%。对原因不明的先天性聋的遗传学研究、多数学者采取系谱调查法,作者认为通过双胎儿的调查研究可能更为合适。为此作者选择自幼儿期即被确定为重度聋的16岁以上的双胎53对,其中一个或两个均无明显的发病原因。对被选者进行详细病史、卵性鉴定、听力学检查和耳鼻喉科检查。在病史上有链霉素中毒、慢性中耳炎等耳聋原因明确者,予以排除,以25对双胎儿做为研究对象。结果:(1)25对双胎年龄在16～29岁之间,卵性鉴定结果:单卵双胎17对,双卵双胎8对。(2)重度耳聋的一致性:听力检查结果双
Severe deafness due to genetic factors accounted for 3.7 ~ 30,1% according to various reports. Genetic studies of congenital deafness of unknown cause, the majority of scholars using pedigree survey method, the author believes that through the study of twin fetuses may be more appropriate. For this reason, the author chose 53 pairs of twins aged 16 years or older who were identified as severe deafness as early childhood, and one or both of them had no obvious cause of the disease. The detailed history, identification of eggs, audiology and otolaryngology were examined. In the history of streptomycin poisoning, chronic otitis media and other causes of deafness were excluded, to 25 pairs of twins as the research object. Results: (1) 25 pairs of twins aged between 16 and 29 years old, the results of egg identification: 17 pairs of monozygotic twins, 8 pairs of twins. (2) the consistency of severe deafness: hearing test results double