血管内凝血和网状内皮系统(RES)抑制可同时见于临床和实验性的损害、如败血症、创伤、烧伤。因此就产生了这一假设,即血管内凝血引起了RES的抑制。为了验证这一理论,给14只清醒的羊静脉注射大肠杆菌内毒素250mcg/kg,其中7只在注射内毒素前按200u/kg静脉推注肝素,注射内毒素后按200u/kg/h作连续滴注。动物观察6小时。通过测定血液中Ⅰ~(123)纤维蛋白元的半衰期及血 Intravascular coagulation and reticuloendothelial system (RES) inhibition can be seen in both clinical and experimental lesions, such as sepsis, trauma, burns. This led to the hypothesis that intravascular coagulation causes repression of RES. In order to validate this theory, 14 awake sheep veins were injected with 250 mcg / kg of E. coli endotoxin, of which 7 were injected intravenously with 200u / kg heparin before injection of endotoxin, 200u / kg / h after endotoxin injection Continuous infusion. Animal observation for 6 hours. By measuring the blood of Ⅰ ~ (123) fibrin half-life and blood