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目的 :观察喉癌患者多药耐药表型与肿瘤化疗反应的关系。方法 :对 3 6例喉癌患者 ,于诱导化疗前取癌组织标本 ,采用免疫组化法检测 P-糖蛋白 ( P- gp)。患者均接受以顺铂、5 -氟尿嘧啶和平阳霉素为方案的术前诱导化疗 ,肿瘤对化疗反应的评估分为有效 (包括完全反应或部分反应 )或无效 (包括稳定或恶化 )。结果 :3 6例中P- gp阳性 12例 ( 3 3 .3 % ) ,P- gp阴性 2 4例 ( 66.7% )。 12例 P- gp阳性患者对化疗反应有效 3例 ( 2 5 % ) ,无效 9例( 75 % ) ;2 4例 P- gp阴性患者对化疗反应有效 2 1例 ( 87.5 % ) ,无效 3例 ( 12 .5 % ) ,P- gp阳性者化疗有效率明显低于 P- gp阴性者 ( P <0 .0 5 )。结论 :本文资料显示 ,以 P- gp介导的多药耐药表型与喉癌对化疗耐药性之间存在统计学意义。
Objective: To observe the relationship between multidrug resistance phenotype and tumor response to chemotherapy in patients with laryngeal cancer. Methods: Tumor specimens of 36 patients with laryngeal carcinoma before chemotherapy were taken and the P-glycoprotein (P-gp) was detected by immunohistochemistry. All patients underwent preoperative chemotherapy with cisplatin, 5 - fluorouracil and pingyangmycin. The response of tumor to chemotherapy was divided into effective (including complete response or partial response) or ineffective (including stable or worsening). Results: Of 36 cases, 12 cases were positive for P-gp (33.3%) and 24 cases (66.7%) were negative for P-gp. Of the 12 patients with P-gp positive response to chemotherapy, 3 (25%) were ineffective and 9 (75%) were ineffective. Twenty-four patients with P-gp negative response to chemotherapy were 21 (87.5%) and 3 (12.5%). The effective rate of chemotherapy for P-gp positive patients was significantly lower than that of P-gp negative patients (P <0.05). Conclusion: The data in this paper shows that there is a significant difference between multidrug resistance phenotype mediated by P- gp and chemoresistance of laryngeal carcinoma.