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目的 :研究糖脂平对实验性糖尿病大鼠坐骨神经糖醇代谢的影响。方法 :四氧嘧啶造型大鼠灌胃给药每日一次 ,疗程一月。结果 :糖脂平有效地降低糖尿病大鼠血糖的含量 ,对坐骨神经中葡萄糖的含量有明显降低作用 ,对山梨醇也有一定降低作用 ,对肌醇含量无明显影响。电镜观察显示 ,糖脂平能改善大鼠坐骨神经脱髓鞘、轴索变性、线粒体肿胀等病理变化。结论 :糖脂平对糖尿病大鼠坐骨神经病变有一定防治效果 ,其作用途径与其降血糖作用与改善神经组织内糖醇代谢有关。
Objective: To study the effect of Tangzhiping on sciatic nerve alcohol metabolism in experimental diabetic rats. Methods : Alloxan-type rats were intragastrically administered once a day for one month. Results: Glucose-lipid can effectively reduce the content of blood glucose in diabetic rats. It has a significant effect on reducing the content of glucose in sciatic nerve. It also has a certain reducing effect on sorbitol, and has no significant effect on inositol content. Electron microscopy showed that GLP could improve the pathological changes of demyelination, axonal degeneration and mitochondrial swelling of the sciatic nerve in rats. Conclusion : Glucose can prevent and cure sciatic nerve neuropathy in diabetic rats. Its action pathway is related to its hypoglycemic effect and improve sugar alcohol metabolism in nerve tissue.