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观察质子泵抑制剂对老年消化性溃疡病人胃内酸度的影响。对经内镜证实的老年溃疡病 2 0例。非老年溃疡病 1 2例 ,测定其 2 4h胃内 p H节律。分别测定治疗前及服质子泵抑制剂 7天时 2 4h胃内 p H动态变化。结果 :老年溃疡病人服药前 ,2 4h p H>4的总时间百分比、中位 p H、平均 p H,分别为 0 .0 6 3、1 .34、1 .92 ;服质子泵抑制剂 7天时 2 4h p H>4的总时间百分比、中位 p H、平均 p H分别为 0 .82、6 .6 8、6 .45 ;与治疗前相比 ,各项指标差异均有显著性意义 (P<0 .0 1 )。非老年病人与老年病人相比 ,用药前后胃内各项 p H指标无明显差异 (P>0 .0 5 )。结论 :老年消化性溃疡病人服用质子泵抑制剂前后 2 4h胃 p H动态变化与非老年溃疡病人大体相同。质子泵抑制剂通过明显增高溃疡病人中位 p H值和 p H>4百分比时间 ,达到治疗作用
To observe the effect of proton pump inhibitor on intragastric acidity in elderly patients with peptic ulcer. Endoscopic confirmed elderly patients with ulcer disease 20 cases. Non-elderly ulcer disease in 12 cases, measured 24 h gastric p H rhythm. The levels of p H in the stomach were measured before and 7 days after treatment with proton pump inhibitor respectively. Results: The percentage of total time p H> 4, median p H, mean p H at 24 h before taking medicine in elderly patients with ulcer were 0.06 3, 1.34, 1.92, respectively; and proton pump inhibitor 7 The total time percentage of p H> 4 at day 24 h, median p H, mean p H were 0.82, 6.66, 8.65, respectively. Compared with those before treatment, there were significant differences in various indexes (P <0. 01). Non-elderly patients compared with elderly patients, before and after treatment of the various indexes of the stomach p H there was no significant difference (P> 0.05). CONCLUSION: The dynamic changes of gastric p H at 24 hours before and after taking proton pump inhibitor in elderly patients with peptic ulcer are generally the same as those in non-elderly patients with ulcer. Proton pump inhibitors achieve therapeutic effect by significantly increasing the median p H value and p H> 4 percentage points of ulcer patients