目的　观察慢性乙型肝炎肝组织窦内皮细胞 (SEC)的形态学改变 ,探讨其与肝脏微循环障碍的关系。方法　对 5 3例慢性乙型肝炎患者进行肝脏活检术 ,肝脏活检组织分别进行光镜和电镜观察。结果　慢性肝炎患者SEC发生了很大变化 ,主要表现在窗孔减小、减少 ,SEC下基底膜形成 ,SEC间出现细胞连接 ,SEC胞质内出现WP小体及SEC脱落现象。随慢性乙型肝炎病变程度加重 ,SEC形态改变愈为显著。SEC与淋巴细胞、库普弗细胞之间亦发生了密切接触。结论　慢性乙型肝炎肝组织的SEC形态上发生了很大变化 ,这可能是肝脏微循环障碍的启动步骤 Objective To observe the morphological changes of hepatic sinusoidal endothelial cells (SECs) in chronic hepatitis B (CHB) and to explore its relationship with liver microcirculation disorder. Methods Fifty-three patients with chronic hepatitis B underwent liver biopsy. The liver biopsies were observed by light microscope and electron microscope respectively. Results The changes of SEC in patients with chronic hepatitis showed great changes. The results showed that there was a decrease in the size of the fenestration, the formation of basement membrane in the SEC, the cell junction in the SEC, the presence of WP bodies and SEC shedding in the cytoplasm of the SEC. With the severity of chronic hepatitis B increased, SEC morphological changes more significant. SEC and lymphocytes, Kupffer cells also occurred between close contact. Conclusion The morphological changes of SEC in liver of patients with chronic hepatitis B have undergone great changes, which may be the initiation step of hepatic microcirculation disorder