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三唑类抗真菌药常用于艾滋病机会性真菌感染的治疗。但该类药物与抗逆转录病毒药物对细胞色素P450酶系统的几个主要代谢酶,都有不同程度的抑制或诱导作用。因此,两类药物之间的相互作用非常复杂,若不进行适当的调整往往影响药物的疗效。该文综述了已公开报道的三唑类抗真菌药与抗逆转录病毒药物之间的相互作用、可能的相互作用机制与处理措施,供临床参考。
Triazole antifungal agents are often used in the treatment of opportunistic fungal infections of AIDS. However, these drugs and antiretroviral drugs on the cytochrome P450 enzyme system of several major metabolic enzymes, have different degrees of inhibition or induction. Therefore, the interaction between the two types of drugs is very complex, which often affects the efficacy of the drug without proper adjustment. This review summarizes the reported interactions between triazole antifungals and antiretroviral drugs, possible interaction mechanisms and treatment measures for clinical reference.