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在各类灾害事故掩埋条件下空气氧含量降低,缺氧缺血成为威胁受灾人员存活的重要因素之一。心脏是对缺氧缺血较为敏感的器官之一,在缺血缺氧的情况下,心脏结构和功能的改变是评价其生命耐受力的关键因素,心肌细胞的凋亡及其发生机制与心脏的结构和功能损伤的病理生理过程也密切相关。目前累积的资料充分表明,在缺血缺氧条件下,凋亡是心肌细胞死亡的重要方式之一,越来越多的证据表明,心力衰竭、心律失常、缺血性心
Under the conditions of landfill of various disasters and accidents, the oxygen content of the air is reduced and hypoxia-ischemia is one of the important factors threatening the survival of the victims. The heart is one of the most sensitive organs for hypoxia and ischemia. In the condition of hypoxia and hypoxia, the change of heart structure and function is the key factor to evaluate the life tolerance, the apoptosis of cardiomyocytes and its mechanism The pathophysiology of the structural and functional impairment of the heart is also closely related. The current accumulated data show that under hypoxic-ischemic conditions, apoptosis is an important way of myocardial cell death. There is more and more evidence that heart failure, arrhythmia, ischemic heart