论文部分内容阅读
通过异基因骨髓移植治疗成人急性白血病4例，其中2例第一次完全缓解（CR1）急性粒细胞白血病，1例CR1急性淋巴细胞白血病，1例急性粒细胞白血病复发。所有病例均采用TBI＋CY＋CCNU作预处理。用小剂量环抱素A（CSA）和短程氨甲蝶呤（MTX）预防急性移植物抗宿主病（aGVHD）。所有病例均移植成功。2例发生aGVHD。1例未缓解病人移植后完全缓解，但于本后69天死于间质性肺炎；2例已分别无病生存19和4个月；余1例（急淋）移植后10个月髓外复发。
Allogeneic bone marrow transplantation was used to treat 4 cases of acute leukemia in adults, including 2 cases of the first complete remission (CR1) of acute myeloid leukemia, 1 case of CR1 acute lymphoblastic leukemia, and 1 case of relapse of acute myelogenous leukemia. All cases were treated with TBI+CY+CCNU. Acute graft-versus-host disease (aGVHD) was prevented with small doses of Ringsalpin A (CSA) and short-range methotrexate (MTX). All cases were successfully transplanted. Two cases of aGVHD occurred. One patient did not respond to complete remission after transplantation, but died of interstitial pneumonitis 69 days later; 2 patients had disease-free survival for 19 and 4 months, respectively; the remaining 1 patient (emergency shower) was extramedullary for 10 months after transplantation. relapse.