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观察棉酚合并 PG0 5对小鼠的抗早孕作用。结果显示 :单用棉酚 75mg/( kg·d) ,3d无抗早孕作用 ,而同样剂量棉酚与 PG0 50 .2 mg/( kg·d) ,合用 2 d可显著增强抗早孕作用 ,使小鼠活胎数进一步减少 ;棉酚 30 μg/ml和 ( - )棉酚 1 5μg/ml对大鼠黄体细胞 3β- HSD活性均有显著抑制作用 ,( + )棉酚 1 5μg/ml和PG0 51 0 μg/ml对此酶活性无影响 ;( - )棉酚 1 5μg/ml还能抑制大鼠颗粒细胞雌二醇的分泌 ,提示棉酚增强 PG0 5抗早孕作用可能是从多环节影响胚胎正常发育。
To observe the anti-pregnancy effect of gossypol combined with PG0 5 on mice. The results showed that ginkol at 75 mg / (kg · d) alone had no effect on early pregnancy, while the same dose of gossypol and PG0 50 .2 mg / (kg · d) The number of alive fetuses in mice was further reduced; gossypol 30 μg / ml and (-) gossypol 15 μg / ml significantly inhibited the 3β-HSD activity of rat luteal cells. 51 0 μg / ml had no effect on this enzyme activity; (-) gossypol 15μg / ml also inhibited the secretion of estradiol in rat granulosa cells, suggesting that gossypol enhanced PG0 5 anti-early pregnancy may be affected from multiple links embryos Normal development.