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目的探讨β-七叶皂甙钠对急性脑梗死患者神经功能及血清TNF-α、IL-6水平的影响。方法急性脑梗死患者91例,随机分为常规治疗组和七叶皂甙钠组,常规治疗组患者根据病情给予常规治疗,七叶皂甙钠组在常规治疗组的基础上加给生理盐水250ml加β-七叶皂甙钠20mg,连续使用14d,两组患者在入院后24h、治疗后7、14、30d进行神经功能缺损评分并抽取静脉血测定TNF-α、IL-6水平。结果两组患者入院24h、治疗后30d血清TNF-α、IL-6水平差异无统计学意义(P>0.05);治疗后7、14d两组患者血清TNF-α、IL-6水平差异具有统计学意义(P<0.05)。两组患者入院24h、治疗后7、14d神经功能缺损评分差异无统计学意义(P>0.05);治疗后30d两组患者神经功能缺损评分差异有统计学意义(P<0.05)。结论β-七叶皂甙钠能够降低急性脑梗死患者血清TNF-αI、L-6水平,改善神经功能缺损评分。
Objective To investigate the effects of β-aescinate on neurological function, serum levels of TNF-α and IL-6 in patients with acute cerebral infarction. Methods A total of 91 acute cerebral infarction patients were randomly divided into conventional treatment group and aesculin sodium group. Patients in the conventional treatment group were given routine treatment according to the condition. Aescinate sodium group was given normal saline 250ml plus β - Aescin 20mg, continuous use of 14d, two groups of patients at admission 24h, 7,14,30 d after treatment of neurological deficit score and venous blood samples were taken for the determination of TNF-α, IL-6 levels. Results There was no significant difference in serum levels of TNF-α and IL-6 between the two groups at admission 24h and 30d after treatment (P> 0.05). There was statistical difference between the two groups in the levels of serum TNF-α and IL-6 Significance (P <0.05). There was no significant difference in neurological deficit score between the two groups at admission for 24h and 7 and 14 days after treatment (P> 0.05). There was significant difference in neurological deficit scores between the two groups at 30 days after treatment (P <0.05). Conclusion β-aescinate sodium can reduce serum levels of TNF-αI and L-6 in patients with acute cerebral infarction and improve neurological deficit scores.