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目的探讨新的药物综合疗法对糖尿病周围神经病变的疗效。方法患者随机分组,对照组42例用维生素C3g、维生素B60.2g、门冬酸钾镁20ml及复方丹参注射液20ml,分别加入250ml生理盐水(NS)内静滴。治疗组45例则给利多卡因0.2g～0.3g、山莨菪碱20mg及复方丹参注射液、黄芪注射液各20ml,分别加入NS250ml内静滴。两组均每日用药1次,14日为1疗程,并根据病情酌用降糖药及对症治疗。结果治疗组显效27例(60%),有效12例(26.7%),总有效率86.7%;明显优于对照组的显效11例(26.2%),有效19例(45.2%)及总有效率71.4%。2组显效率有极显著差异(P<0.01),总有效率有显著差异(P<0.05)。结论新的药物综合疗法对糖尿病周围神经病变安全有效。
Objective To explore the effect of new drug combination therapy on diabetic peripheral neuropathy. Methods A total of 42 patients in the control group were given intravenous infusion of 250g normal saline (NS) with vitamin C3g, vitamin B60.2g, potassium aspartate 20mg and compound Danshen injection 20ml respectively. 45 cases of treatment group to lidocaine 0.2g ~ 0.3g, anisodamine 20mg and compound Danshen injection, astragalus injection 20ml each, were added NS250ml intravenous infusion. The two groups were daily medication 1, 14 for a course of treatment, and according to the condition of hypoglycemic agents and symptomatic treatment. Results The effective rate of treatment group was 27 cases (60%), effective rate was 12.7% (26.7%), the total effective rate was 86.7%, significantly higher than that of the control group (26.2%), effective rate of 19 cases (45.2% 71.4%. There was significant difference between the two groups (P <0.01). The total effective rate was significantly different (P <0.05). Conclusion New drug combination therapy is safe and effective for diabetic peripheral neuropathy.