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【目的】探讨大环内酯抗生素治疗儿童I型慢性鼻窦炎的疗效。【方法】应用大环内酯抗生素治疗儿童I型慢性鼻窦炎 84 0例。【结果】84 0例患者治疗后随访观察 6～ 30个月。痊愈者 4 35例 ,占 5 1.8% ,好转者 316例 ,占 37.6 % ,总有效率为 89.4 % ,无效者 89例 ,占 10 .6 %。Ⅰ期的痊愈率和有效率优于Ⅱ期和Ⅲ期 ,Ⅱ期的痊愈率和有效率优于Ⅲ期。应用琥乙红霉素、罗红霉素和克拉霉素三种不同大环内酯类抗生素治疗的痊愈率和有效率无明显差异。【结论】①应用大环内酯类抗生素治疗儿童Ⅰ型慢性鼻窦炎是一种较有效的方法 ;②Ⅰ型儿童慢性鼻窦炎的病变越轻 ,应用大环内酯类抗生素治疗效果越好 ;③应用琥乙红霉素、罗红霉素和克拉霉素三种不同大环内酯类抗生素治疗效果无明显差异。
【Objective】 To investigate the curative effect of macrolide antibiotics on children with chronic type Ⅰ chronic sinusitis. 【Method】 840 cases of type I chronic sinusitis were treated with macrolide antibiotics. 【Results】 84 0 patients were followed up for 6 to 30 months after treatment. There were 435 cases of recovery, accounting for 5 1.8%, 316 cases of improvement, accounting for 37.6%, the total effective rate was 89.4%, ineffective in 89 cases, accounting for 10.6%. The cure rate and effective rate of stage Ⅰ are better than stage Ⅱ and stage Ⅲ, and the cure rate and effective rate of stage Ⅱ are better than stage Ⅲ. Application of erythromycin erythromycin, roxithromycin and clarithromycin three different macrolide antibiotics cure rate and efficiency no significant difference. Conclusion: ① macrolide antibiotics in children with chronic type Ⅰ chronic sinusitis is a more effective method; ② type Ⅰ children with chronic sinusitis lesions lighter, macrolide antibiotics better treatment effect; ③ Application of erythromycin ethylsuccinate, roxithromycin and clarithromycin three different macrolide antibiotics treatment effect no significant difference.