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目的：探讨高原急性出血坏死性胰腺炎所致胰源性猝死者的临床病理改变。方法：７例猝死者行尸检，对全身系统脏器作病理组织观察。结果：无痛、昏迷、休克为主要表现，多器官损害为其特征，以肺水肿最突出占１００％ ，心脏受累和脑水肿分别占８５．７％ 。脂餐、饮酒、胆石不是主要因素，药物及多种应激因素应予重视。结论：低容量休克、急性肺水肿、脑水肿、急性心力衰竭是猝死的重要原因。高原缺氧对促进胰腺组织坏死起着一定作用。
Objective: To investigate the clinicopathological changes of patients with sudden pancreatitis due to acute hemorrhagic necrotizing pancreatitis in the plateau. Methods: Seven cases of sudden death were examined by autopsy and the pathological tissues of the whole body were observed. Results: Painless, coma and shock were the main manifestations. Multiple organ damage was the characteristic, with the most prominent pulmonary edema accounting for 100%, heart involvement and cerebral edema accounting for 85.7%. Fat meal, alcohol consumption, gallstone is not a major factor, drugs and a variety of stress factors should be attention. Conclusion: Low-volume shock, acute pulmonary edema, cerebral edema and acute heart failure are the important causes of sudden death. Plateau hypoxia plays a role in promoting pancreatic tissue necrosis.