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几乎所有的抗生素对不同的菌种都有一定的后效作用。所谓后效作用,即抗生素与细菌短期接触之后去药培养,细菌仍持续一段时间表现出生长受抑。本文对国产新药利福定的后效作用及后效作用方式作了考察及分析。用普通营养肉汤将金色葡萄球菌209p培养到对数生长期,加入利福定和利福平,使药浓为10MlC,药物与菌液接触时间为0.5小时及2小时后,去药培养,于不同时间取样,用(~3H)—尿嘧核苷前体掺入法观察定量菌液在不同时间中RNA合成速度(按定量菌体中所含的
Almost all of the antibiotics have some effect on different species. The so-called after-effect, that is, antibiotics and bacteria to short-term exposure to drug culture, the bacteria continued to show growth for some time suppressed growth. This article made a review and analysis of the after-effect and after-effect mode of domestic new drug Rifidin. With normal nutrition broth Staphylococcus aureus 209p cultured to logarithmic growth phase, adding rifadin and rifampicin, so that drug concentration 10MlC, drug and bacterium liquid contact time of 0.5 hours and 2 hours after drug cultivation, Samples were collected at different times and RNA synthesis rate (determined by quantification of bacterial cells