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肾素血管紧张素醛固酮系统在肾脏疾病的进展中起着重要作用。醛固酮是这一系统中造成肾脏损害的重要物质,醛固酮可能通过血流动力学改变和直接作用于肾脏固有细胞发挥肾损伤效应,醛固酮受体拮抗药能够拮抗醛固酮的作用,延缓肾脏疾病的进展,保护肾功能。
The renin-angiotensin aldosterone system plays an important role in the progression of kidney disease. Aldosterone is an important substance in this system that causes kidney damage. Aldosterone may exert renal injury through hemodynamic changes and direct action on innate cells in the kidney. Aldosterone receptor antagonists can antagonize the effect of aldosterone and delay the progression of kidney disease. Protect renal function.