INTRODUCTIONrnEstrin attaches importance to development of skeleton and sustain of bone quantity.Level of estrin drops significantly after mentopause and rebuilding of bone loses balance.Absorption of bone is more than synthesis of bone and losing rate rate of bone fastens.The accelerated losing of bone occurs in the period of menstrual disorder perimenopausal period. To healthy worn, losing quantity of bone accounted for 3% to 10% on first year of menopause and 6% to 14%on second and third year.It is estimated that woman will lose 50%of bone quantity of lumbar vertebrae and 30% of bone quantity of corter, which was respectively 30% and 20% in man. The loss of skeleton after menopause occurs firetly at lumbar vertebrae and spongy bone in the end of long bone, which was often combined with changes of bonne structure Generally speaking,once bone quantity drops 10%, the risk of fracture adds one time.rn