癫痫是神经系统常见病之一,是由脑内神经元异常放电所致,具有突然、反复发作的特点,其发病机制异常复杂。近年来随着医学分子生物学技术迅速发展,发现细胞外信号调节激酶(ERK1/2)在脑内含量丰富[1],在神经元的胞体、树突上大量表达,可以将胞外刺激信号如神经递质、神经营养因子 Epilepsy is one of the most common neurological diseases caused by abnormal discharge of neurons in the brain with sudden and recurrent seizures. Its pathogenesis is extremely complicated. In recent years, with the rapid development of medical molecular biology technology, it has been found that extracellular signal-regulated kinase (ERK1 / 2) is abundant in the brain [1] and is abundantly expressed in the somatic cells and dendrites of neurons. Extracellular stimulating signals Such as neurotransmitters, neurotrophic factors