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目的:探讨原发性IgA肾病的病理特征与蛋白尿的相关性。方法:对2010年6月至2011年6月我院收治的72例原发性IgA肾病患者根据尿蛋白量将患者分为高蛋白尿组(A组,29例)和低蛋白尿组(B组,43例),通过半定量积分法对两组病理参数进行比较分析。结果:与A组比较,B组在肾小管总积分、系膜增殖程度积分、球性硬化积分、肾小管间质积分上均有显著性差异(P<0.05)。结论:原发性IgA肾病的病理类型呈现多样性,并且各种类型之间存在着一定的相关性,可根据患者的临床表现及相关辅助检查,尤其是蛋白尿程度进行初步病理疹断分型,为临床治疗及预后判断提供依据。
Objective: To investigate the relationship between pathological features of primary IgA nephropathy and proteinuria. Methods: From June 2010 to June 2011, 72 patients with primary IgA nephropathy admitted to our hospital were divided into high proteinuria group (group A, n = 29) and low proteinuria group (group B) Group, 43 cases). The pathological parameters of the two groups were compared by semi-quantitative integration method. Results: Compared with group A, group B had significant difference in total tubule score, mesangial proliferation score, sclerosis score and tubulointerstitial score (P <0.05). Conclusion: The pathological types of primary IgA nephropathy are diverse, and there is a certain correlation between various types. According to the clinical manifestations of patients and related auxiliary examinations, especially the degree of proteinuria preliminary pathological rash classification , To provide the basis for clinical treatment and prognosis.