论文部分内容阅读
该文旨在检测电压依赖性钙离子通道基因CACNA1A和CACNA1C与血压变化和高血压发病率的关系。方法:盐敏感性遗传流行病学协作(genetic epidemiology network of salt sensitivity,GenSalt)随访研究中1768名符合入选条件的汉族人参与本次研究。使用随机零点血压计共获得基线和每次随访时测量的9个血压值。混合效应模型用于评估CACNA1A和CACNA1C基因的176个单核苷酸多态性(single
The aim of this study was to examine the relationship between the voltage-dependent calcium channel genes CACNA1A and CACNA1C and the changes of blood pressure and the incidence of hypertension. METHODS: A total of 1768 Han Chinese eligible for inclusion in the salt-sensitive genetic epidemiology network of salt sensitivity (GenSalt) follow-up study participated in this study. A total of 9 blood pressure values were measured at baseline and at each follow-up using a random zero sphygmomanometer. The mixed-effects model was used to assess the 176 single nucleotide polymorphisms of the CACNA1A and CACNA1C genes