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肌腱蛋白C属于细胞外基质糖蛋白,其在正常成人组织中几乎不可检测到,成人组织TNC表达上调通常与炎症、损伤、肿瘤新生等疾病状态有关。本文就TNC的分子结构以及在组织纤维化中的作用等方面的研究进展作一综述。
Tenascin C belongs to the extracellular matrix glycoprotein, which is almost undetectable in normal adult tissues. The upregulation of TNC expression in adult tissues is usually associated with disease states such as inflammation, injury and neoplasia. This article reviews the molecular structure of TNC and its role in tissue fibrosis.