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目的:探寻热毒宁吸人溶液递送剂量信息和气溶胶粒径信息之间的相关性。方法:选择绿原酸、梔子苷为指标成分,采用呼吸模拟器测定递送剂量均一性,利用新一代微粒撞击收集仪测定空气动力学粒径分布,运用实时喷雾粒度分析仪测定实时喷雾粒径分布,将递送剂量信息组与粒径信息组进行相关性分析。结果:两变量组组内多数原始变量具有较强的相关性,原始变量组间相关性优劣不一。经典型相关分析后,提取出2对相关性显著的典型变量,其相关系数分别为0.998和0.955。递送剂量组接近90%的信息和粒径组超过70%的信息能够被这2对典型变量所概括。结论:对于热毒宁吸人溶液递送剂量信息和气溶胶粒径信息,原始变量组内相关性良好,组间相关性参差不齐。相比原始变量,典型变量呈现出了较好的组间相关性,表明递送剂量信息和粒径信息有一定的相关性,且提取出的2对典型变量能够较好的预测两组内的原始变量。
OBJECTIVE: To explore the correlation between the information on the delivery dose of thermotolerate solution and aerosol particle size. Methods: Chlorogenic acid and geniposide were selected as index components. The uniformity of delivered dose was measured by breath simulator. The aerodynamic particle size distribution was determined by a new generation of microparticle impingement collector. The real-time spray particle size analyzer Distribution, the dose information delivered dose group and size information group correlation analysis. Results: Most of the original variables in the two-variable group had strong correlation, and the correlations among the original variables were different. After the classical correlation analysis, two pairs of typical variables with significant correlation were extracted, and the correlation coefficients were 0.998 and 0.955 respectively. Nearly 90% of the delivered dose group information and more than 70% of the particle size group information can be summarized by these 2 pairs of typical variables. CONCLUSIONS: For the information on the delivered dose and the aerosol particle size of the thermotolerate inhalation solution, the correlation between the original variable group was good and the inter-group correlation was mixed. Compared with the original variables, the typical variables showed a good correlation between groups, indicating that there is a certain correlation between delivery dose information and particle size information, and the extracted two pairs of typical variables can better predict the original variable.