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目的 建立同时测定藏药七味铁屑丸中土木香内酯、异土木香内酯、去氢木香内酯和木香烃内酯的GC法.方法 HP-5毛细管色谱柱 (30 m×0.32 mm, 0.25μm);FID检测器;柱温箱温度140℃, 进样口温度220℃, 检测器温度250℃;载气为氮气, 流速为1.0 m L·min-1, 空气流速450 m L·min-1, 氢气流速45 m L·min-1;进样量1μL;分流比20︰1.结果 土木香内酯、异土木香内酯、去氢木香内酯和木香烃内酯的线性范围分别为7.120 2～71.202 2μg·m L-1 (r=0.998 4);5.478 5～54.785 1μg·m L-1 (r=0.997 1);8.195 3～98.344 1μg·m L-1 (r=0.996 7);6.395 4～76.744 8μg·m L-1 (r=0.997 2);平均回收率分别为98.11％ (RSD=1.04％), 98.12％ (RSD=1.09％), 98.39％ (RSD=1.26％), 97.52％ (RSD=1.25％) .结论 本方法可有效可靠地对七味铁屑丸中藏木香和木香进行定量控制.“,”OBJECTIVE To estahlish a method for the simultaneous determination of alantolactone, isoalantolactone, dehydrocostuslactone and costunolide in Tibetan medicine Qiwei Tiexue pill by GC. METHODS Samples of Qiwei Tiexue pill were determined by HP-5 capillary column (30 m×0.32 mm, 0.25 μm). The column oven temperature was 140 ℃. FID was used as detector with a temperature of 250 ℃, and the inlet temperature was 220 ℃. The carries gas was nitrogen and the flow rate of carries gas was 1.0 m L·min-1. The air flow rate was 450 m L·min-1. The hydrogen flow rate was 45 m L·min-1. The injection volume was 1 μL. Split ratio was 20:1. RESULTS The linear ranges of alantolactone, isoalantolactone, dehydrocostuslactone and costunolide were 7.120 2-71.202 2 μg·m L-1 (r=0.998 4); 5.478 5-54.785 1 μg·m L-1 (r=0.997 1); 8.195 3-98.344 1 μg·m L-1 (r=0.996 7); 6.395 4-76.744 8 μg·m L-1 (r=0.997 2), with average recoveries (n=6) of 98.11％ (RSD=1.04％), 98.12％ (RSD=1.09％), 98.39％ (RSD=1.26％), 97.52％ (RSD=1.25％), respectively. CONCLUSION This method is effective and reliable, which can be used for quality control for the determination of Inula racemosa and Aucklandia lapp in Qiwei Tiexue pill.