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目的:探讨肺癌影像学表现与其癌细胞 C D44 表达的关系。方法: 利用免疫组化方法 L S A B 法测定46 例经手术及病理证实的非小细胞肺癌组织中 C D44 的表达强度,分析其表达强度与影像学征象的相关关系。结果:肿块毛刺征、三级支气管受累及肺门纵隔淋巴结转移在 C D44 表达阳性组的出现率明显高于阴性组( P< 0 .01 ) ;而肿块大小、分叶征及胸膜凹陷征在两组之间的出现率无明显差异( P> 0 .05) 。结论:外围型非小细胞癌之肿块毛刺征、三级支气管受累及肺门纵隔淋巴结转移与癌细胞 C D44 的表达密切相关。
Objective: To investigate the relationship between the imaging manifestations of lung cancer and the expression of C D44 in cancer cells. Methods: The expression of C D44 in 46 cases of non-small cell lung cancer confirmed by surgery and pathology was determined by immunohistochemical method L S A B . The correlation between the expression intensity and imaging signs was analyzed. Results: The incidence of tumor burr sign, grade 3 bronchial involvement and hilar mediastinal lymph node metastasis in the C D44 positive group was significantly higher than that in the negative group (P < 0.01). The size of the tumor, lobular sign and pleural depression sign were There was no significant difference between the two groups (P > 0.05). CONCLUSIONS: Tumor burr sign, tertiary bronchial involvement and mediastinal lymph node metastasis in peripheral non-small cell carcinoma are closely related to the expression of C D44 in cancer cells.