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纳米脂质体是一类直径大小在10至数百纳米之间的脂质体。由于其特殊的尺度范围,同时具有脂质体的生物相容性等优良特征,纳米脂质体被广泛应用于肿瘤防治的临床前研究和临床应用。本文介绍了纳米脂质体的特征以及影响其效果的因素,并对近年来将纳米脂质体作为运输载体用于改善传统化疗药物治疗效果、体内运送siRNA以及在分子影像等方面的研究进行综述。
Nanosomes are a group of liposomes that have a diameter of between 10 and several hundred nanometers. Due to its special scale range and the excellent characteristics of biocompatibility of liposomes, nano-liposomes are widely used in preclinical research and clinical application of tumor prevention and treatment. In this paper, the characteristics of nano-liposomes and the factors that affect their effect are introduced. In the last few years, the application of nano-liposomes as transport carriers to improve the therapeutic effect of traditional chemotherapy drugs, siRNA delivery in vivo, and molecular imaging are reviewed .