许多具有生物活性的天然产物及药物均含有手性芳基叔醇结构单元,金属催化芳基硼酸与酮不对称1,2-加成反应是合成该类化合物的有效方法.由于芳基硼酸具有官能团兼容性好、对水及空气稳定、低毒等优点,近来已经成为化学家研究的热点.就近年来金属催化芳基硼酸与活泼酮如靛红、三氟甲基酮、α-酮酯及1,2-二酮和不活泼酮的不对称1,2-加成的研究进展做一详细综述. Many biologically active natural products and pharmaceuticals contain chiral aryl tertiary alcohol structural units, and metal-catalyzed asymmetric 1,2-addition of arylboronic acid to ketones is an effective method for the synthesis of such compounds. Since arylboronic acids have Functional groups compatibility, water and air stability, low toxicity and other advantages, has recently become a chemist research hot spots.In recent years, metal-catalyzed aryl boronic acid and active ketone such as isatin, trifluoromethyl ketone, α-ketoester and 1,2-dione and inactive ketone asymmetric 1,2-addition to make a detailed review of the progress.