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目的研究单硝酸异山梨酯对慢性肾功能衰竭患者肾功能的改善作用。方法选择我院18例住院患者在应用非透析保守治疗的同时,应用单硝酸异山梨酯药物治疗(治疗组)7~10 d;选择我院11例住院患者应用非透析保守治疗(对照组)7~10 d,并观察对比疗效。结果治疗组肾功能明显改善(P<0.01),对照组无明显改善(P>0.05)。结论单硝酸异山梨酯类药物具有延缓慢性肾功能衰竭的发展、改善肾功能的作用。
Objective To study the effect of isosorbide mononitrate on renal function in patients with chronic renal failure. Methods 18 hospitalized patients in our hospital were treated with isosorbide mononitrate (treatment group) for 7-10 days while non-dialysis conservative treatment was used. Eleven patients in our hospital were treated with non-dialysis conservative treatment (control group) 7 ~ 10 d, and observe the effect of contrast. Results The renal function of the treatment group was significantly improved (P <0.01), but there was no significant improvement in the control group (P> 0.05). Conclusion Isosorbide mononitrate can delay the development of chronic renal failure and improve renal function.