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三磷酸胞苷(CTP)有防止和缓解血管硬化的作用。利用离体蟾蜍心脏.观察到CTP 2.5×10~(-1)g/ml可使心缩增强,心率减慢。用氯仿引起小鼠室颤来观察CTP的抗室颤作用,结果表明CTP(0.5g/kg,ip)可使室颤率降低到20%,与对照组(室颤率90%)比较P<0.05。通过离体兔耳血管灌流,证实了CTP(2.5mg/次)对正常状态的血管灌流量影响不大,但对去甲肾上腺素引起的灌流量下降能使其显著回升(P<0.01)。作者还用肾上腺素引起离体兔主动脉条挛缩,再用CTP解痉,结果显示1×10~(-3)和2×
Cytidine triphosphate (CTP) has the effect of preventing and relieving vascular sclerosis. Using the isolated toad heart, it was observed that CTP 2.5 × 10 -1 g / ml could enhance systolic and heart rate. Chloroform induced ventricular fibrillation in mice to observe the anti-ventricular fibrillation CTP, the results showed that CTP (0.5g / kg, ip) can reduce the rate of ventricular fibrillation to 20%, compared with the control group (90% ventricular fibrillation) P < 0.05. Vascular perfusion through isolated rabbit ear demonstrated that CTP (2.5mg / time) had little effect on normal blood vessel perfusion but decreased norepinephrine-induced perfusion significantly (P <0.01). The author also used adrenaline caused isolated rabbit aortic contracture, and then spasm CTP, the results showed that 1 × 10 ~ (-3) and 2 ×