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目的探讨金茵利胆口服液辅助治疗新生儿高胆红素血症的临床疗效及安全性。方法选取2012年1月-2014年9月该院新生儿科收治的高胆红素血症患儿80例为研究对象,随机分为金茵利胆组和常规组,每组各40例。常规组采用常规疗法进行治疗,金茵利胆组在常规组基础上加用金茵利胆口服液,两组患儿均以治疗7 d为1个疗程,比较两组患儿临床疗效的差异。结果治疗前,两组患儿的TBIL、IBIL、AST、LDH、CK、y-GGT、Cys-C、MAD水平比较,差异无统计学意义(P>0.05);治疗后,上述指标较治疗前均显著好转,差异有统计学意义(P<0.05)。金茵利胆组患儿在治疗后第3、7天的TBIL、IBIL检测值和黄疸消退时间显著低于常规组(P<0.05);TBIL、IBIL日均下降值显著高于常规组(P<0.05);AST、LDH、CK、y-GGT、Cys-C、MAD检测值显著优于常规组(P<0.05);显效率高于常规组(P<0.05)。结论金茵利胆口服液辅助治疗新生儿高胆红素血症能够缩短治疗时间,缓解患儿心肌、肝肾功能的损伤,从而进一步提高临床疗效。
Objective To investigate the clinical efficacy and safety of Jin Yin Li Gan oral liquid adjuvant treatment of neonatal hyperbilirubinemia. Methods Eighty children with hyperbilirubinaemia admitted to neonatology department of our hospital from January 2012 to September 2014 were selected and randomly divided into Jin Yin Li gall group and conventional group, 40 cases in each group. The conventional group was treated by conventional therapy. The Jin Yin Li gall group was treated with Jin Yin Li Gan oral liquid on the basis of the conventional group. Both groups were treated for 7 days for one course of treatment. The differences of clinical curative effect between the two groups were compared. Results Before treatment, there was no significant difference in the levels of TBIL, IBIL, AST, LDH, CK, y-GGT, Cys-C and MAD between the two groups (P> 0.05) Were significantly improved, the difference was statistically significant (P <0.05). The TBIL and IBIL values and jaundice remission time of children in Jinyin gall group were significantly lower than those in the conventional group (P <0.05) on the 3rd and 7th days after treatment. The daily average of TBIL and IBIL decreased significantly (P <0.05) ); The detection values of AST, LDH, CK, y-GGT, Cys-C and MAD were significantly better than those of the conventional group (P <0.05); Conclusions The adjuvant treatment of Jin Yin Li and Gan Oral Liquid in neonates with hyperbilirubinaemia can shorten the treatment time and relieve the myocardial, liver and renal dysfunction in children, so as to further improve the clinical curative effect.