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本文报道应用放射免疫法测定106例先天性心脏病、心肌病及心律失常患儿血清地高辛浓度,其中全程维持量组(19例)为1.11±0.6毫微克/毫升,饱和量组(15例)为1.22±0.72毫微克/毫升,两组比较无显著差异(P>0.05)。长期维持量组(30例)为0.78±0.47毫微克/毫升。中毒组(3例)为4.65～5.3毫微克/毫升。结合临床观察,全程维持量组患儿的心衰症状亦有明显改善,提示对慢性心衰患儿可不必用饱和量,只要用全程维持量同样有效且安全。但在本组中未用地高辛组89例患儿中有15例测出地高辛,浓度为0.1～0.55毫微克/毫升,所以在评价地高辛血清浓度时要注意非特异性凝集影响的可能.
This article reports the determination of serum digoxin concentrations in 106 children with congenital heart disease, cardiomyopathy and arrhythmia by radioimmunoassay, in which the total maintenance dose (19 cases) was 1.11 ± 0.6 ng / ml and the saturation dose group Cases) was 1.22 ± 0.72 ng / ml, no significant difference between the two groups (P> 0.05). The long-term maintenance dose group (30 patients) was 0.78 ± 0.47 ng / mL. Toxicity group (3 cases) was 4.65 ~ 5.3 ng / ml. Combined with clinical observation, the whole course of maintenance of children with heart failure symptoms also significantly improved, suggesting that children with chronic heart failure may not need to use saturation, as long as the full use of the same amount of maintenance and safety. However, in this group of digoxin-free group of 89 cases of children with 15 measured digoxin, the concentration of 0.1 ~ 0.55 ng / ml, so in the evaluation of digoxin serum concentration should pay attention to the impact of non-specific agglutination may.