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家族性乳腺癌与遗传易感基因的突变有密切的联系 ,目前已发现多种乳腺癌遗传易感基因 ,它们分别定位于 17号和 13号染色体的长臂和 8号染色体的短臂上。乳腺癌家族中易感基因突变携带者患乳腺癌的危险性明显高于普通人群 ,具有不同易感基因突变的乳腺癌患者其组织学特征也有所不同。本文就家族性乳腺癌遗传易感基因的研究进展作一综述
Familial breast cancer is closely related to genetic susceptibility gene mutations. At present, a variety of breast cancer genetic susceptibility genes have been discovered. They are located on the long arm of chromosomes 17 and 13 and the short arm of chromosome 8, respectively. The risk of breast cancer in people with susceptibility gene mutations in the breast cancer family is significantly higher than that in the general population, and the histological characteristics of breast cancer patients with different susceptibility gene mutations are also different. This article reviews the research progress of genetic susceptibility genes in familial breast cancer.