应用放免法测定了60名正常人和120例高血压病患者血浆β内啡肽(β-EP),亮啡肽(L-EK),神经降压肽(NT)、精氨酸升压素(AVP)、肾素活性(PRA)和血管紧张素Ⅱ(AT Ⅱ)含量。结果发现高血压病患者血浆β-EP和L-EK含量明显降低(P<0.01),血浆AVP、PRA和AT Ⅱ水平明显升高(P<0.01,P<0.05,P<0.05),NT含量与正常组无明显差别。血浆L-EK与平均动脉压呈负相关(r=-0.196,P<0.05),而AVP与病程呈正相关(r=0.216,P<0.05)。结果提示,某些神经肽的分泌异常可能参与高血压病的形成和维持。 The levels of plasma β-EP, L-EK, NT, Arginine-Vasopressin in 60 normal subjects and 120 hypertensive patients were determined by radioimmunoassay (AVP), renin activity (PRA) and angiotensin Ⅱ (AT Ⅱ) content were measured. The results showed that the plasma levels of β-EP and L-EK in patients with essential hypertension were significantly lower (P <0.01), the levels of AVP, PRA and AT Ⅱ in plasma were significantly higher (P0.01, P0.05, P0.05) No significant difference with the normal group. Plasma L-EK was negatively correlated with mean arterial pressure (r = -0.196, P <0.05), while AVP was positively correlated with duration (r = 0.216, P <0.05). The results suggest that the abnormal secretion of certain neuropeptides may be involved in the formation and maintenance of hypertension.