【摘 要】
：
Plants and plant derivatives are natural sources of valuable material for the discovery and development of new antiviral materials due to their high availabilit
【机 构】
：
Institutes of Biology and Medical Sciences, Jiangsu Key Laboratory of Infection and Immunity, Soocho
论文部分内容阅读
Plants and plant derivatives are natural sources of valuable material for the discovery and development of new antiviral materials due to their high availability in nature and expected low side effects [1].In fact, the extract from plants has displayed good antiviral effects comparing with their synthetic analogues [2].More and more natural products derived from diverse parts of plants have been used as antiviral drugs during the past several decades, such as baicalein, emodin, dandelion, and berberine [3-6].Cyclocytidine hydrochloride (Fig.1A), an anhydride analogue of cytosine arabinoside (araC), has been used in medicine as clinical chemotherapeutics with strong antileukemic activity [7].Previous studies also showed that cyclocytidine hydrochloride exhibits high antiviral activity against DNA virus, such as herpes simplex virus (HSV) andcytomegalovirus (CMV) [8-10].However, whether this natural compound has impact on RNA virus is still unknown.So it gives us great interest to investigate the mechanisms of cyclocytidine hydrochloride under RNA virus infection.
其他文献
Multiple primary malignant neoplasms are defined as two or more metachronous or synchronous separate neoplasms in the same organ or different sites [1].Multiple
Eimeria acervulina severely damages the intestinal mucosa in infected poultry, resulting in major economic losses [1].The study of the interaction between Eimer
目的 探讨子宫下段剖宫产手术损伤输尿管的原因、诊断、防治措施.方法 回顾性分析响水县人民医院自2007-01-2010-12子宫下段剖宫产损伤输尿管的临床表现,诊断及处理.结果 3例
目的 探讨胸腰椎骨折手术治疗的疗效.方法 47例胸腰椎骨折的患者均行后路椎弓根螺钉及植骨,其中18例行后路椎板减压.结果 47例均获得随访,平均随访13个月(6～24个月).45例获得
目的 探讨形状记忆合金环抱器治疗连枷胸的手术疗效.方法 对18例连枷胸患者采取形状记忆合金环抱器内固定术治疗.结果 经6～48个月随访,平均14个月,优良率为100%,无死亡病例,未
Eukaryotic cells have multiple membrane organelles within the cell.One of the cellular challenges is to direct proteins,especially membrane proteins,to the righ
目的观察沐舒坦(氨溴索)佐治毛细支气管炎的临床疗效。方法选择100例毛细支气管炎患儿,随机分为治疗组和对照组。对照组予以抗炎、止痉、雾化吸入、肾上腺皮质激素及博利康尼
Erectile dysfunction (ED) is a problem getting or keeping an erection hard enough for satisfactory sexual performance.A wide variety of ways have been recommend
Polycyclic aromatic hydrocarbons (PAHs) are a broad class of semivolatile organic compounds considered to be dangerous environmental pollutants.They are ubiquit