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目的:探讨血浆凝血因子Ⅶ(FⅦ)基因R353Q多态性的分布与河南汉族人冠状动脉粥样硬化性心脏病(CHD)的关系。方法:利用PCR-RFLP分析技术,检测264例健康对照组和207例河南汉族CHD患者FⅦ基因R353Q多态性。结果:2组FⅦ基因R353Q基因型频率均符合Hardy-Weinberg平衡。CHD患者RR纯合型频率高于正常对照组(P<0.05),Q等位基因频率(RQ+QQ)低于正常对照组(P<0.05)。结论:河南汉族人群中存在FⅦ基因R353Q多态性,其中Q等位基因可能是冠心病的遗传保护因子。
Objective: To investigate the relationship between the distribution of plasma coagulation factor Ⅶ (FⅦ) gene R353Q polymorphism and coronary atherosclerotic heart disease (CHD) in Han nationality in Henan province. Methods: PCR-RFLP analysis was used to detect the polymorphism of FⅦ gene R353Q in 264 healthy controls and 207 Han patients with CHD in Henan province. Results: The frequency of R353Q genotypes of FⅦ gene in two groups all accorded with Hardy-Weinberg equilibrium. RR homozygote of CHD patients was higher than that of normal control group (P <0.05), Q allele frequency (RQ + QQ) was lower than that of normal control group (P <0.05). Conclusion: The FⅦ gene R353Q polymorphism exists in Henan Han population. The Q allele may be the genetic protective factor of coronary heart disease.